It is mainly used to prevent heart disease by blocking the formation of the plaque, clots, platelet clumping and increase the flow of blood to the arteries.

Indications:

⇒ Used to treat dietary imbalances
⇒ Pituitary Dwarfism
⇒ Acromegaly

About Composition:

L–Arginine is used as supplement that has improved immune responses to bacteria, viruses and tumour cells; promotes wound healing and regeneration of the liver; causes the release of growth hormones; considered crucial for optimal muscle growth and tissue repair. It acts as precursor to nitric oxide or NO. NO is produced by all tissues of the body and plays very important roles in the cardiovascular system, immune system and nervous system. NO is formed from L-arginine via the enzyme nitric oxide synthase or synthetase (NOS), and the effects of NO are mainly mediated by cyclic guanylate or cyclic GMP. NO activates the enzyme guanylate cyclase, which catalyses the synthesis of cyclic GMP from guanosine triphosphate or GTP. Cyclic GMP is converted to guanylic acid via the enzyme cyclic GMP phosphodiesterase. NOS is a heme-containing enzyme with some sequences similar to cytochrome P-450 reductase. Several isoforms of NOS exist, two of which are constitutive and one of which is inducible by immunological stimuli. The constitutive NOS found in the vascular endothelium is designated eNOS and that present in the brain, spinal cord and peripheral nervous system is designated nNOS.

Pharmacokinetics:

⇒ It is absorbed from small intestine
⇒ It is metabolized in the enterocytes of the small intestine

Side Effects:

⇒ Bloating
⇒ Abdominal pain
⇒ Diarrhoea
⇒ Bradycardia
⇒ inflammation of airways
⇒ Gout

Contraindication:

Contraindicated in acute heart attack